The following papers offer a good introduction to STAR (i.e. “sphere-templated”) biomaterial:
- A pore way to heal and regenerate: 21st century thinking on biocompatibility, Ratner BD, Regenerative Biomaterials, 2016, 107–110.
- Bryers JD, Giachelli CM, Ratner BD. Engineering biomaterials to integrate and heal: The biocompatibility paradigm shifts, Biotechnology and Bioengineering 109(8): 1898-1911, 2012.
For more on STAR‘s anti-fibrotic properties:
- Madden LR, Mortisen DJ, Sussman EM, Dupras SK, Fugate JA, Cuy JL, Hauch KD, Laflamme MA, Murry CE, Ratner BD. Proangiogenic Scaffolds as Functional Templates for Cardiac Tissue Engineering. Proc Nat Acad Sci, Published Electronically, Aug 9, 2010.
For more on the scientific basis of STAR‘s anti-infection properties:
- Porous Implants Modulate Healing and Induce Shifts in Local Macrophage Polarization in the Foreign Body Reaction, Sussman, Halpin, Muster, Moon, Ratner, Annals of Biomedical Engineering, Vol. 42, No. 7, July 2014.
And contrasting STAR with other porous biomaterials:
- Medical Applications of Porous Biomaterials: Features of Porosity and Tissue‐Specific Implications for Biocompatibility, JL Hernandez, KA Woodrow, Advanced Healthcare Materials, 2022.
OTHER PAPERS AND BOOK CHAPTERS
Ratner B, Vascular Grafts: Technology Success / Technology Failure, BME Frontiers, 2023, Vol. 4, Article 0003.
Pourjavan S, Collignon N, De Groot V, Eiferman RA, Marshall AJ, Roy CJ. STARflo™: A Suprachoroidal Drainage Implant Made from STAR® Biomaterial, Surgical Innovations in Glaucoma: eds. Samples JR, Ahmed IIK. Springer Science+Business Media 2014.
Marshall AJ. Capillary network inside silicone STAR™ pore structure, with red blood cells surrounded by vascular endothelial cells and macrophages lining walls of pores, Biotechnology and Bioengineering109(8): Aug 2012 (Cover Picture).
Fleckman P, Usui M, Zhao G, Underwood R, Maginness M, Marshall A, Glaister C, Ratner B, Olerud J. 2011. Cutaneous and Inflammatory Response to Long-Term Percutaneous Implants of Sphere-Templated Porous/Solid Poly(HEMA) and Silicone in Mice. J. Biomed. Mater. Res., 100A: 1256–1268. doi: 10.1002/jbm.a.34012
Underwood RA, Usui ML, Zhao G, Hauch KD, Takeno MM, Ratner BD, Marshall AJ, Shi X, Olerud JE, Fleckman P. Quantifying the Effect of Pore Size and Surface Treatment on Epidermal Incorporation into Percutaneously Implanted Sphere-Templated Porous Biomaterials in Mice. J Biomaterials Research Part A, Wiley DOI: 10.1002.jbm.a.33125, Published Electronically, Jun 16, 2011.
Fukano Y, Usui ML, Underwood RA, Isenhath S, Marshall AJ, Hauch KD, Ratner BD, Olerud JE, Fleckman P. Epidermal and Dermal Integration into Sphere-Templated Porous Poly (2-Hydroxyethyl Methacrylate) Implants in Mice. J Biomed Mater Res, Published Electronically, Apr 2010.
Ratner BD, Atzet S, Barbucci R, ed. Hydrogels for Healing. Springer-Verlag, Milan, 43-51, 2009.
Osathanon T, Linnes ML, Rajachar RM, Ratner BD, Somerman MJ, Giachelli CM. Microporous Nanofibrous Fibrin-based Scaffolds for Bone Tissue Engineering. Biomaterials, 29(30) 4091-9, 2008.
Ratner BD, Tooley MH, et al. Biomedical Engineering Desk Reference. London: Academic, 2008.
Bryers JD. Medical Biofilms. Biotechnology and Bioengineering, 100(1): 1-18, 2008.
Bhrany AD, Lien CJ, Beckstead BL, Futran ND, Muni NH, Giachelli CM, Ratner BD. Crosslinking of an Oesophagus Acellular Matrix Tissue Scaffold. J. Tissue Engineering and Regenerative Medicine, 2(6) 365-372, 2008.
Mortisen DJ. Scaffolds as Functional Templates for Cardiac Tissue Engineering. PhD Dissertation, University of Washington: 2008.
Fleckman P, Olerud J. Models for the Histologic Study of the Skin Interface with Percutaneous Biomaterials. Biomed. Mater, 3(3):034006 (6pp), 2008.
Ratner BD. A Paradigm Shift: Biomaterials that Heal. Polymer International, 56(10): 1183-1185, 2007.
Linnes MP, Ratner BD, Giachelli CM. A Fibrinogen-Based Precision Microporous Scaffold for Tissue Engineering. Biomaterials, 28(35): 5298-5306, 2007.
Bryant SJ, Cuy JL, Hauch KD, Ratner BD. Photo-patterning of Porous Hydrogels for Tissue Engineering. Biomaterials, 28(19): 2978-86, 2007.
Isenhath SN, Fukano Y, Usui ML, Underwood RA, Irvin CA, Marshall AJ, Hauch KD, Ratner BD, Fleckman P, Olerud JE. A Mouse Model to Evaluate the Interface between Skin and a Percutaneous Device. J Biomed Mater Res, 83A: 915–922, 2007.
Bhrany AD, Beckstead BL, Lang TC, Farwell DG, Giachelli CM, Ratner BD. Development of an Esophagus Acellular Matrix Tissue Scaffold. Tissue Engineering, 12(2): 319-30, 2006.
Fukano Y, et al. Characterization of an In Vitro Model for Evaluating the Interface Between Skin and Percutaneous Biomaterials. Wound Repair and Regeneration, 14, 484-491, 2006.
Beckstead BL, Pan S, Bhrany AD, Bratt-Leal AM, Ratner BD, Giachelli CM. Esophageal Epithelial Cell Interaction with Synthetic and Natural Scaffolds for Tissue Engineering. Biomaterials 26, 6217-6228, 2005.
Marshall, AJ and Ratner BD, Quantitative Characterization of Sphere-Templated Porous Biomaterials. AIChE Journal, 51(4): 1221-1232, 2005.
Knowles NG et al. A Model for Studying Epithelial Attachment and Morphology at the Interface Between Skin and Percutaneous Devices. Journal of Biomedical Materials Research A. 74(3):482-8, 2005.
Marshall AJ. Porous Hydrogels with Well-Defined Pore Structure for Biomaterials Applications. PhD Dissertation, University of Washington: 2004.
Ratner BD, Bryant SJ. Biomaterials: Where We Have Been and Where We are Going. Annual Reviews of Biomedical Engineering, 6, 41-75 2004.
Marshall, AJ, Irvin CA, Barker T, Sage, KD, Hauch EH, Ratner BD. Biomaterials with Tightly Controlled Pore Size that Promote Vascular In-Growth. ACS Polymer Preprints, 45(2): 100-101, 2004.
PRESENTATIONS
Marshall AJ, Oda A, Scanlan B, Maginness M. Microporous Textured Exterior Biointerface Prevents Stenosis in Arteriovenous Grafts. Society for Biomaterials Annual Meeting. Charlotte, NC, April 2015.
Pourjavan S, Collignon N, De Groot V, Geens P, Maginness M, Marshall AJ, Roy C, Alvarez M. STARflo™, a new suprachoroidal drainage implant for glaucoma: 3 month clinical results. European Association for Vision and Eye Research (EVER) 2012. Nice, France, October 2012.
De Groot V, Collignon N, Pourjavan S, Geens P, Maginness M, Marshall AJ, Roy C, Alvarez M. STARflo™, a new suprachoroidal drainage implant for glaucoma: 6 month clinical results. 6th International Congress on Glaucoma Surgery. Glasgow, Scotland, September 2012.
Marshall AJ, Nieponice A, Alvarez M, Maginness M. An Infection Control Solution for Catheter Exit Sites: Translation from Mice to Device. 3rd World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS), Vienna, Austria, September 2012.
Marshall AJ, Nieponice A, Oda A, Glaister C, Alvarez M, Maginness M.
Macrotextured Microporous Surface Structure Reduces Fibrotic Encapsulation of Subcutaneous Silicone Implants. Tissue Engineering and Regenerative Medicine International Society North America (TERMIS). Orlando, FL. December 2010.
Kanayama K, Yoshimatsu T, Garty S, Kim BY, Ratner BD, Wong RO, Shen TT. Imaging the Dynamics of Corneal Epithelial Cell-Polymer Integration Using Multiphoton Microscopy. Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting. Fort Lauderdale, FL, May, 2010.
Fleckman P, Underwood R, Usui M, Zhao G, Marshall AJ, Maginness M, Glaister C, Ratner BD, Olerud J. Cutaneous Response to Long Term Percutaneous Porous/Solid Biomaterial Implants in a Mouse Model. Society for Investigative Dermatology Annual Meeting. Atlanta, GA, May, 2010.
Marshall AJ, Garty S, Kanayama S, Shen TT, Ratner BD, Woods C, Maginness MG. Sphere Templated Angiogenic Regeneration (STAR®) for Ophthalmic Applications. Society for Biomaterials Annual Meeting. Seattle, WA, April 2010.
Long TJ, Sprenger CCT, Stephen R. Plymate SR, Ratner BD. Sphere-Templated Hydrogels for 3D Observation of Prostate Cancer Cell Growth and Tumor Formation. Society for Biomaterials Annual Meeting. Seattle, WA, April 2010.
López EA, Simonovsky FI, Bassuk JA, Ratner BD. Biodegradable Spherical Porous Polyurethane Scaffold for Urinary Bladder Tissue Engineering. Society for Biomaterials Annual Meeting. Seattle, WA, April 2010.
Sussman EM, Madden LR, Ratner BD. Pore Size of Implanted Biomaterials Modulated Macrophage Polarity. Society for Biomaterials Annual Meeting. Seattle, WA, April 2010.
Ratner BD. Healing and Regeneration Moves the Biointerface into Three Dimensions. Materials Research Society Fall Meeting. Boston, MA, November 2009.
Marshall AJ, Maginness, MG, Metter RB, Burdick JA. Sphere Templated Angiogenic Regeneration (STAR®) Scaffolds from Crosslinked Hyaluronic Acid. 2nd World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS). Seoul, Korea, August 2009.
Marshall AJ. Glaister CL, Maginness, MG. Injectable Sphere Templated Angiogenic Regeneration (STAR®) Scaffolds. 2nd World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS). Seoul, Korea, August 2009.
Marshall AJ, Maginness MG, Glaister CL, Woods C, Metter RB, Burdick JA. Sphere Templated Angiogenic Regeneration (STAR®) Scaffolds for Device Biointegration and Wound Repair. Polymers in Medicine and Biology, Santa Rosa, CA, June 2009.
Marshall AJ, Maginness MG, Sphere Templated Angiogenic Regeneration (STAR™) Biomaterial for Reducing Infection Associated with Percutaneous Devices. Society for Biomaterials Annual Meeting, San Antonio, TX, April 2009.
Tavakkol Z, Marshall AJ, Fleckman P, Ratner BD, Olerud J. Porous Silicone: A Promising Material for Sealing the Skin-Biomaterial Interface. Journal Invest Dermatol, 127 (S1):S37, 2007.
Marshall AJ et al. Controlled Pore Size: A Promising Path to Long-Term Implantable Glucose Sensors. Vascular Matrix Biology and Vascular Engineering Workshop, Whistler, BC, March 2007.
Miyashita Y, Isenhath SN, Usui ML, Underwood RA, Hauch KD, Irvin CA, Marshall AJ, Ratner BD, Fleckman P, Olerud JE. Skin Cell Attachment to an Implanted Percutaneous Biomaterial: A Mouse Model. Wound Rep and Reg, 13(2):A6, 2005.
Miyashita Y, Usui ML, Underwood RA, Hauch KD, Marshall AJ, Ratner BD, Fleckman P, Olerud JE. Effects of Surface Modification and Pore Size of Poly (2-hydroxyethyl methacrylate) on Cutaneous Cell Adhesion and Biointegration. Society for Investigative Dermatology, #194, May 2005.
Isenhath SN, Usui ML, Underwood RA, Miyashita Y, Irvin CA, Ciridon WA, Hauch KD, Fleckman PH, Ratner BD, Olerud JE. Skin Cell Attachment to an Implanted Transcutaneous Biomaterial: A Mouse Model. J Invest Dermatol, 122(3):A37, 2004.
Miyashita Y, Knowles NG, Usui ML, Underwood RA, Hauch KD, Marshall AJ, Ratner BD, Giachelli CM, Carter WG, Olerud JE: Keratinocyte Biointegration to Poly (2 hydroxyethyl methacrylate) (pHEMA) Implants. J Invest Dermatol, 121(1):#260, 2003.
Miyashita Y, Knowles NG, Usui ML, Hauch KD, Ciridon WA, Carter WG, Olerud JE. A Systematic Study of Percutaneous Biomaterial Interfaces. Wound Healing Society Meeting, May 2002.
Knowles NG, Usui ML, Gibran NS, Ratner BD, Hauch KD, Olerud JE. A Model for Studying Keratinocyte Morphology and Attachment at the Interface between Skin and Percutaneous Devices. J Invest Dermatol, 117(2):418, 2001.